Browsing Master of Biotechnology by Issue Date

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A Novel Mutation in GPR98 gene detected by Next Generation Sequencing Causes Hearing Loss in a Palestinian Family

Anabtawi, Abeer (Palestine Polytehnic University & Bethlehem University, 4/1/2014)

Inherited hearing loss is a genetically heterogeneous disease. Screening patients to detect genes and mutations represents a major challenge. Next generation sequencing is used to overcome this challenge. The primary purpose ...
Novel Mutations in Msx1 and Kremen1 are Responsible for Nonsyndromic and Syndromic Hypodontia in the Palestinian Population

Issa, Yasmin Ali (Palestine Polytehnic University & Bethlehem University, 5/1/2014)

Background: Hypodontia is the most common developmental anomaly in humans. It occurs as a consequence to disruption of genes involved in the signaling pathways of tooth development. Mutations in candidate genes such as ...
Linkage Exclusion of FBXO10 Locus as a Cause of Hearing Impairment in Selected Palestinian Families with the Disease

Qabaja, Bayan Mohammad (Palestine Polytechnic University and Bethlehem University, 8/1/2014)

Hearing loss is a common sensory disorder that typically illustrates genetic heterogeneity in human populations. About 1 in 1000 new born suffer a form of hearing loss where approximately half of all cases have genetic ...
Promoter Methylation Status of PTEN Tumor Suppressor Gene among Palestinian Breast Cancer Patients

Al-Ajrami, Mariam (Palestine Polytehnic University & Bethlehem University, 9/1/2014)

Background: The phosphatase and tensin homolog (PTEN) gene, is a tumor suppressor gene located on chromosome 10q23. Several studies showed that 30-40% of sporadic breast cancer cases show a loss of PTEN protein levels due ...
Molecular Phylogeny of Palestinian Date Palm Cultivars by Microsatellite Simple Sequence Repeats and Inter Simple Sequence Repeats Markers

Al-Shouli, Hala (Palestine Polytehnic University & Bethlehem University, 11/1/2014)

Date palm (Phoenix dactylifera L.) is considered one of the major fruit crops in Palestine and one of the oldest cultivated plants. Date crops contribute to the economical, industrial, and religious concepts in the Middle ...
Identification of a Novel Mutation in LRP6 Gene Responsible for Non-Syndromic Hypodontia in a Palestinian Family

Shokeh, Yasmeen (Palestine Polytehnic University & Bethlehem University, 12/1/2014)

Background: Hypodontia is considered one of the most common developmental anomalies in humans. It is defined as the missing of one or more primary or secondary teeth which results in disturbances during the early stages ...
Induction, Elicitation and Determination of Total Anthocyanin Secondary Metabolites from In vitro Growing Cultures of Arbutus andrachne L

Jaber, Abla Ghassan (Palestine Polytehnic University & Bethlehem University, 12/1/2014)

Anthocyanin pigments are important secondary metabolites that produced in many plant species. They have wide range of uses in food and pharmaceutical industries as antioxidant and food additives. Medically, they prevent ...
Factors Affecting In Vitro Culture of Asphodelus aestivus l. and Secondary Metabolites Production

Alshawamreh, Loay (Palestine Polytehnic University & Bethlehem University, 12/1/2014)

Asphodelus aestivus L. (Liliaceae), Arabic name “Gysalan” is a geophytes plant distributed all over the Mediterranean region. It has been used in traditional (folk) medicine to treat skin disease, jaundice, and psoriasis. ...
Identification of Susceptible Copy Number Variants in a Palestinian Family affected with Intellectual Disability

Darwish, Alaa (Palestine Polytehnic University & Bethlehem University, 12/1/2014)

Intellectual disability (ID) is a common problem with major implications for the public health, education and community services. The causes of mental retardation have been found to have a definite etiological basis, which ...
Elicitation, Analysis, and Biological Activity of Secondary Metabolites of Ziziphus spina-christi (L.) Desf. In Vitro Cultures

Hawamda, Watan (Palestine polytechnic university & Bethlehem university, 1/1/2015)

Ziziphus spina-christi (L.) Desf. (Rhamnaceae) or “Christ's Thorn”, "Sider" in Arabic is an evergreen tree widely distributed in the Mediterranean region, North and East Africa. It has been used in traditional medicine to ...
In-frame Three Base Pair Deletion Causes Achromatopsia disease in Six Palestinian Families

Shiebat, Fadwa (Palestine Polytehnic University & Bethlehem University, 6/1/2015)

Achromatopsia is a rare autosomal recessive disease that affects vision and leads to total color blindness. Achromatopsia patients suffer from photophobia, nystagmus, cataracts, reduced visual acuity, and eccentric fixation. ...
“The effect of electronic waste (e- waste) on DNA and chromosomes in Idhna, Hebron District, Occupied Palestine”

Khlaif, Nadia (Palestine Polytehnic University & Bethlehem University, 9/1/2015)

Electronic waste (e-waste) is solid waste which accumulates because of short life span of electronic equipments. The major problem of e-waste is recycling that use primitive techniques such as dumping in landfills or ...
“Mutation Analysis for Five Palestinian Families Affected by Isolated Congenital Methylmalonic Acidemia”

Sarhaneh, Hanan (Palestine Polytehnic University & Bethlehem University, 12/1/2015)

Background: Isolated Methylmalonic acidemia (MMA) is a heterogeneous autosomal-recessive metabolic disorder caused 60% by mutations in the vitamin B12-dependent enzyme methylmalonyl-CoA mutase (MUT). Shortage of this ...
Novel Mutations for Nonsyndromic Cleft Lip and Palate in Two Consanguineous Palestinian Families

Abu Geith, Rawan (Palestine polytechnic university& Bethlehem University, 12/1/2015)

Cleft lip and\or palate (CL/ CP) is the most common congenital malformation that affects the upper lip and the roof of the mouth. It is one of the most frequent congenital anomalies, affecting 1 in every 500 to 1000 births ...
Identification of novel mutations in ASPM and KMT2D Genes responsible for Primary Microcephaly and Kabuki-like syndrome in Palestinian Families

AWAD, AYA (Bethlehem University &Palestinian Polytechnic University, 3/1/2016)

ABSTRACT Background: Microcephaly is considered a neurodegenerative syndrome, in which the head circumference is at least 2 SD below average which differs according to age and gender. In most cases Microcephaly is associated ...
SNaPshot Multiplex Assay for Rapid Detection of Mutations Associated with Hereditary Hearing Loss in Palestine

Jaraysa, Tamara Saber (Palestine Polytechnic University & Bethlehem University, 4/1/2016)

Background: Hearing loss is the most common sensory disorder affecting a high rate of newborns especially in Palestine. Hearing loss incidence increases with the high rate of consanguinity observed in the Palestinian ...
A novel Splice Site Mutation in ADGVR1 Detected in Palestinian Family with Hearing Loss by Next Generation Sequencing

Tomizy, Fida (Palestine Polytehnic University & Bethlehem University, 4/1/2016)

Background: hereditary deafness is a genetically heterogeneous trait. To date, 60 genes that have been identified that cause nonsyndromic hearing loss. The extreme genetic heterogeneity of deafness makes the ability to ...
Characterization of Antibiotic Resistance and Virulence Genes in Shigella Species Isolated from Patient Samples from Southern Palestine

Salah, Muna Kamal Ismael (Palestine Polytechnic University & Bethlehem University, 5/1/2016)

Shigella is a Gram-negative rod-shaped bacteria from the Enterobacteriaceae family, classified into four species; S. dysenteriae, S. flexneri, S. sonnei, and S. boydii. Shigella species cause shigellosis, which is transmitted ...
Characterization of Orf virus Loads in Ecthymous Scabs for Autologous Vaccine Development in Palestinian Sheep

Abu Shkhaidem, Dua’a (Palestine Polytechnic University, Bethlehem University, 6/1/2016)
“Identification of a Rare Splice Site Mutation in a Palestinian Family With West Syndrome”

Dweik, Hamza (Palestine Polytechnic University, Bethlehem University, 6/1/2016)

West Syndrome is a convulsive disorder consists of a triad of a unique seizure type (spasms), hypsarrhythmia, and developmental arrest or regression. It begins in infancy, mostly between 4 and 6 months of life. Its incidence ...

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