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Vitamin D Deficiency in the Palestinian Population

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dc.contributor.author Abusarhan, Mohammed
dc.date.accessioned 2022-05-24T09:30:08Z
dc.date.available 2022-05-24T09:30:08Z
dc.date.issued 2022-01-01
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/8506
dc.description no of pages 37 , 31109, ماجستير تكنولوجيا حيوية 1/2022
dc.description.abstract Objectives: Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D Deficiency (VDD) is a global pandemic with higher prevalence rates among Palestinians. Programs for supplying Vitamin D (VD) were carried out by the Ministry of Health and UNICEF but the issue did not resolve. In this study, we aim to (a) investigate the genetic variants of VD genes among the Palestinian population; and (b) investigate the efficacy of calcitriol vs D3 supplementation. Methods: For genetic assessment, alleles on SNPs rs10741657 (CYP121) and rs7041 (GC) were investigated in 69 Palestinians. For calcitriol efficacy, 106 individuals joined in phase 1 for 1 month, and 92 individuals joined in phase 2 for 3 months. Results: 94.2% of the 69 individuals assayed had reduced CYP2R1 and/or GC enzyme activity with a higher risk for developing VDD. Calcitriol efficacy in elevating VD levels is significantly higher than D3. Keywords: Calcitriol, CYP2R1, D3 Supplementation. en_US
dc.language.iso en en_US
dc.publisher جامعة بوليتكنك فلسطين - تكنولوجيا حيوية en_US
dc.subject Vitamin D en_US
dc.title Vitamin D Deficiency in the Palestinian Population en_US
dc.type Other en_US

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