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Liver cell therapy: is this the end of the beginning?

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dc.contributor.advisor Hay, David C.
dc.contributor.author Alwahsh, Salamah M
dc.contributor.author Rashidi, Hassan
dc.contributor.author Hay, David C.
dc.date.accessioned 2021-05-04T07:59:58Z
dc.date.accessioned 2022-05-22T08:54:39Z
dc.date.available 2021-05-04T07:59:58Z
dc.date.available 2022-05-22T08:54:39Z
dc.date.issued 2018-04
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/29181772/
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/8308
dc.description.abstract The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is widely used to treat liver disease upon organ failure. The complexity of this procedure and finite numbers of healthy organ donors have prompted research into alternative therapeutic options to treat liver disease. This includes the transplantation of liver cells to promote regeneration. While successful, the routine supply of good quality human liver cells is limited. Therefore, renewable and scalable sources of these cells are sought. Liver progenitor and pluripotent stem cells offer potential cell sources that could be used clinically. This review discusses recent approaches in liver cell transplantation and requirements to improve the process, with the ultimate goal being efficient organ regeneration. We also discuss the potential off-target effects of cell-based therapies, and the advantages and drawbacks of current pre-clinical animal models used to study organ senescence, repopulation and regeneration. en_US
dc.description.sponsorship The project was funded by awards from the Medical Research Council MR/K026666/1 and MR/L022974/1. en_US
dc.language.iso en_US en_US
dc.publisher SpringerLink en_US
dc.subject Biomaterials; Cell sheet; Cell tracking; Co-culture; Differentiation; Engraftment; Extracellular matrix; Hepatic progenitor cells; Hepatocyte-like cells (HLCs); Mesenchymal stem cells (MSCs) en_US
dc.title Liver cell therapy: is this the end of the beginning? en_US
dc.type Article en_US

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