dc.contributor.author |
Fry, Elizabeth |
|
dc.contributor.author |
Lea, Susan |
|
dc.contributor.author |
Jackson, Terry |
|
dc.contributor.author |
Newman, John WI |
|
dc.contributor.author |
Ellard, Fiona M |
|
dc.contributor.author |
Blakemore, Wendy |
|
dc.contributor.author |
Abu Ghazaleh, Robin |
|
dc.contributor.author |
Samuel, Alan |
|
dc.contributor.author |
King, Andrew |
|
dc.contributor.author |
Stuart, David I |
|
dc.date.accessioned |
2020-11-23T07:37:15Z |
|
dc.date.accessioned |
2022-05-22T08:53:11Z |
|
dc.date.available |
2020-11-23T07:37:15Z |
|
dc.date.available |
2022-05-22T08:53:11Z |
|
dc.date.issued |
1999 |
|
dc.identifier.citation |
Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI. The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. EMBO J. 1999 Feb 1;18(3):543-54. doi: 10.1093/emboj/18.3.543. PMID: 9927414; PMCID: PMC1171147. |
en_US |
dc.identifier.uri |
http://localhost:8080/xmlui/handle/123456789/8164 |
|
dc.description.abstract |
Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The binding site is a shallow depression on the virion surface, located at the junction of the three major capsid proteins, VP1, VP2 and VP3. Two pre-formed sulfate-binding sites control receptor specificity. Residue 56 of VP3, an arginine in this virus, is critical to this recognition, forming a key component of both sites. This residue is a histidine in field isolates of the virus, switching to an arginine in adaptation to tissue culture, forming the high affinity heparan sulfate-binding site. We postulate that this site is a conserved feature of FMDVs, such that in the infected animal there is a biological advantage to low affinity, or more selective, interactions with glycosaminoglycan receptors. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
The EMBO Journal |
en_US |
dc.title |
The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex |
en_US |
dc.type |
Article |
en_US |