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The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex

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dc.contributor.author Fry, Elizabeth
dc.contributor.author Lea, Susan
dc.contributor.author Jackson, Terry
dc.contributor.author Newman, John WI
dc.contributor.author Ellard, Fiona M
dc.contributor.author Blakemore, Wendy
dc.contributor.author Abu Ghazaleh, Robin
dc.contributor.author Samuel, Alan
dc.contributor.author King, Andrew
dc.contributor.author Stuart, David I
dc.date.accessioned 2020-11-23T07:37:15Z
dc.date.accessioned 2022-05-22T08:53:11Z
dc.date.available 2020-11-23T07:37:15Z
dc.date.available 2022-05-22T08:53:11Z
dc.date.issued 1999
dc.identifier.citation Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI. The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. EMBO J. 1999 Feb 1;18(3):543-54. doi: 10.1093/emboj/18.3.543. PMID: 9927414; PMCID: PMC1171147. en_US
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/8164
dc.description.abstract Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The binding site is a shallow depression on the virion surface, located at the junction of the three major capsid proteins, VP1, VP2 and VP3. Two pre-formed sulfate-binding sites control receptor specificity. Residue 56 of VP3, an arginine in this virus, is critical to this recognition, forming a key component of both sites. This residue is a histidine in field isolates of the virus, switching to an arginine in adaptation to tissue culture, forming the high affinity heparan sulfate-binding site. We postulate that this site is a conserved feature of FMDVs, such that in the infected animal there is a biological advantage to low affinity, or more selective, interactions with glycosaminoglycan receptors. en_US
dc.language.iso en en_US
dc.publisher The EMBO Journal en_US
dc.title The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex en_US
dc.type Article en_US

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