Browsing Scientific Published Papers by Author "Mandelboim, Ofer"

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Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma.

Nachmias, Boaz; Ashhab, Yaqoub; Bucholtz, Vered; Drize, Olga; Kadouri, Luna; Lotem, Michal; Peretz, Tamar; Mandelboim, Ofer; Ben-Yehuda, Dina (2003-10-01)

Inhibitor of apoptosis protein (IAP) is a family of intracellular proteins that plays an essential role in the regulation of apoptosis. Recently, we and others discovered a new member of this family, termed Livin. Many ...
Manipulation of NK cytotoxicity by the IAP family member Livin.

Nachmias, Boaz; Mizrahi, Sa'ar; Elmalech, Meital; Lazar, Itay; Ashhab, Yaqoub; Gazit, Roi; Markel, Gal; Ben-Yehuda, Dina; Mandelboim, Ofer (2007-12)

Natural killer (NK) cells are part of the innate immune system, capable of killing tumor and virally infected cells. NK cells induce apoptosis in the target cell by either granule- or receptor-mediated pathways. A set of ...

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