Abstract:
In the world of genomic research, projects aimed at revealing the complete
sequence of a given genome are usually cumbersome and tedious. The major
problem in these projects is that the long sequence of the genome should pass
two processes; 1) randomly cutting it into a huge number of short DNA
sequences known as Whole genome-shotgun reads (WGSRs ), 2) thereafter
using computer programs to reconstruct the whole genome sequence. The main
drawback during the reconstruction process is the small fragments that come
from duplicated segment in the original genome. Segmental duplication is a
well known phenomenon which refers to blocks of DNA sequence that exist in
more than one copy in the genome. The objective of my project is to develop a
Windows-based system that can efficiently analyze and delineate segmental
duplications. in WGSRs databases. The main advantage of this system is its
simplicity for users as well as capability to be used for any WGSRs database.
Perl was used for developing this system because it is a very strong language in
string processing and analysis. In addition, Perl has many bioinformatics
modules that can facilitate programming for biological applications.
Description:
no of pages 104, 18796, تكنولوجيا المعلومات 7/2006 , in the store
