Towards a Knowledgebase For Caspases Substrates

Abstract

CT The idea of the project is to develop a huge and user friendly knowledge database that contains all proteins which are cleaved by Caspases enzymes. The proteins are represented graphically to facilitate the analysis and studying of the Caspases substrates. Each protein file contains rich information such as the cleaving Caspase(s), the exact cleavage position, functional domains, biological implications of the cleavage process, and links for the pathway and interaction for each protein. The database offers easy to use searching tools that allow simple as well as advanced search. The database will be freely available via a web site through Palestine Polytechnic University's server. The unique feature of this database is its ability to evolve through the contribution of browsers (biologists) from all around the world. The browsers can contribute to grow the database through adding more Caspases substrates or editing already available data. The contributions of browsers were designed in a way to ensure high security data entry as well as to minimize effort needed by the administrators to follow-up and validate the contributions. In addition, our database is capable to update its content by recent data that is available through such as Uniprot and PubMed