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Browsing by Author "Blakemore, Wendy"

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Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro

Jackson, Terry; Sharma, A; Abu Ghazaleh, Robin; Blakemore, Wendy; Ellard, Fiona; Simmons, D; Newman, John; Stuart, David; King, Andrew (American Society for Microbiology, 1997-11-01)

The integrin alpha(v)beta3 has been shown to act as the receptor for internalization of foot-and-mouth disease virus (FMDV) (A12), with attachment being through a highly conserved RGD motif located on the G-H loop of viral ...
Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus

Curry, Stephen; Abu Ghazaleh, Robin; Blakemore, Wendy; Fry, Elizabeth; Jackson, Terry; King, Andrew; Logan, Derek; Newman, John; Stuart, David (Academic Press, 1992-12-20)

Foot-and-mouth disease viruses from serotypes O, A and C have been crystallized. The particular strains studied include O1K, A1061, A22 Iraq 24/64, A24 Cruzeiro and C-S8c1. In addition, crystals have been grown of G67, a ...
Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus

Curry, Stephen; Fry, Elizabeth; Blakemore, Wendy; Abu Ghazaleh, Robin; Jackson, Terry; King, Andrew; Lea, Susan; Newman, John; Stuart, David (American Society for Microbiology, 1997-01-12)

Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64, whose structure has been solved by X-ray crystallography, are unusual for picornaviruses since they contain VP2 and VP4, the cleavage products of ...
Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate

Jackson, Terry; Ellard, Fiona; Abu Ghazaleh, Robin; Brookes, Sharon; Blakemore, Wendy; Corteyn, Amanda; Stuart, David; Newman, JW; King, AM (American Society for Microbiology, 1996-08-01)

Foot-and-mouth disease virus (FMDV) enters cells by attaching to cellular receptor molecules of the integrin family, one of which has been identified as the RGD-binding integrin alpha(v)beta3. Here we report that, in ...
Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate

Jackson, Terry; Ellard, Fiona; Abu Ghazaleh, Robin; Brookes, S; Blakemore, Wendy; Corteyn, A; Stuart, David; Newman, John; King, Andrew (American Society for Microbiology, 1996-08-01)

Foot-and-mouth disease virus (FMDV) enters cells by attaching to cellular receptor molecules of the integrin family, one of which has been identified as the RGD-binding integrin alpha(v)beta3. Here we report that, in ...
Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity

Curry, Stephen; Fry, Elizabeth; Blakemore, Wendy; Abu Ghazaleh, Robin; Jackson, Terry; King, Andrew; Lea, Susan; Newman, John; Rowlands, David; Stuart, David (Cell Press, 1996-02-29)

Background: Foot-and-mouth disease virus (FMDV) is an extremely infectious and antigenically diverse picornavirus of cloven-hoofed animals. Strains of the A22 subtype have been reported to change antigenically when adapted ...
Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity

Curry, Stephen; Fry, Elizabeth; Blakemore, Wendy; Abu Ghazaleh, Robin; Jackson, Terry; King, Andrew; Lea, Susan; Newman, John; Rowlands, David; Stuart, David (Cell Press, 1996-02-29)

Background: Foot-and-mouth disease virus (FMDV) is an extremely infectious and antigenically diverse picornavirus of cloven-hoofed animals. Strains of the A22 subtype have been reported to change antigenically when adapted ...
Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67

Lea, Susan; Abu Ghazaleh, Robin; Blakemore, Wendy; Curry, Stephen; Fry, Elizabeth; Jackson, Terry; King, Andrew; Logan, Derek; Newman, John; Stuart, David (Cell Press, 1995-06-30)

Background: Foot-and-mouth disease viruses (FMDVs) are members of the picornavirus family and cause an economically important disease of cloven-hoofed animals. To understand the structural basis of antigenic variation in ...
The structure and antigenicity of a type C foot-and-mouth disease virus

Lea, Susan; Hernendez, J; Blakemore, Wendy; Curry, Stephen; Fry, Elizabeth; Abu Ghazaleh, Robin; King, Andrew; Newman, John; Stuart, David; Mateu, M (Cell Press, 1994-02-28)

Background Picornaviruses are responsible for a wide range of mammalian diseases and, in common with other RNA viruses, show considerable antigenic variation. Foot-and-mouth disease viruses (FMDVs) constitute one genus of ...
The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex

Fry, Elizabeth; Lea, Susan; Jackson, Terry; Newman, John WI; Ellard, Fiona M; Blakemore, Wendy; Abu Ghazaleh, Robin; Samuel, Alan; King, Andrew; Stuart, David I (The EMBO Journal, 1999)

Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif ...

Browsing by Author "Blakemore, Wendy"

Browsing by Author "Blakemore, Wendy"

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