Browsing by Author "Wheeler-Jones, Caroline"

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Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A in endothelial cells via p42/p44 mitogen-activated protein kinase 2

Wheeler-Jones, Caroline; Abu Ghazaleh, Robin; Cospedal, Rosario; Houliston, Rebecca; Martin, John; Zachary, Ian (FEBS Letters, 1997-12)

Vascular endothelial growth factor (VEGF) stimulated a time- and concentration-dependent increase in PGI2 synthesis in human umbilical vein endothelial cells with a mean maximum increase of 2-fold above basal levels at 25 ...
Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-d and by mobilization of intracellular Ca 2 +

Gliki, Georgia; Abu Ghazaleh, Robin; Jezequel, Sylvie; Wheeler-Jones, Caroline; Zachary, Ian (Biochemistry Journal, 2001-02)

We reported previously that vascular endothelial growth factor (VEGF) stimulates prostacyclin (PGI(2)) production via activation of the extracellular signal-regulated kinase (ERK) cascade. In this paper, we examined the ...

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