Define Runs of Homozygosity in a Cohort of Palestinian Families

tamimi, yasmin

dc.contributor.advisor	kanan, moien
dc.contributor.author	tamimi, yasmin
dc.date.accessioned	2017-02-26T09:48:33Z
dc.date.accessioned	2022-05-11T05:45:28Z
dc.date.available	2017-02-26T09:48:33Z
dc.date.available	2022-05-11T05:45:28Z
dc.date.issued	8/1/2016
dc.identifier.uri	http://test.ppu.edu/handle/123456789/192
dc.description	DC 29499- ON. OF PAGES-38	en_US
dc.description.abstract	Objective: The aim of this study is to define runs of homozygosity (ROH) in a cohort of Palestinian families. Methods: Defining ROH depends on using data of single nucleotide polymorphism (SNP) locations, and the lengths of shared homozygous segments. By using data from 197,701 SNP panel in 29 individuals from southern area of Palestine, we reflect the potential significance of defining ROH. Results: In all individuals, regions of ROH were identified; these regions were mapped and their genes content were revaluated. Conclusion: Genes located within ROH regions may have significant causes of deleterious variants that could be inherited in concordance with homozygosity runs.	en_US
dc.language.iso	en	en_US
dc.publisher	Palestine Polytechnic University &Bethlehem University	en_US
dc.subject	SCIENCE	en_US
dc.title	Define Runs of Homozygosity in a Cohort of Palestinian Families	en_US
dc.type	Thesis	en_US